Molecular characterization of influenza A(H1N1)pdm09 in Cameroon during the 2014-2016 influenza seasons
Identifieur interne : 000066 ( Main/Exploration ); précédent : 000065; suivant : 000067Molecular characterization of influenza A(H1N1)pdm09 in Cameroon during the 2014-2016 influenza seasons
Auteurs : Chavely Gwladys Monamele [Cameroun] ; Hermann Landry Munshili Njifon [Cameroun] ; Marie-Astrid Vernet [Cameroun] ; Mohamadou Ripa Njankouo [Cameroun] ; Sebastien Kenmoe [Cameroun] ; Ali Ahmed Yahaya ; Louis Deweerdt [Cameroun] ; Raphael Nono [Cameroun] ; Wilfred Mbacham [Cameroun] ; Damian Nota Anong [Cameroun] ; Jane Francis Akoachere [Cameroun] ; Richard Njouom [Cameroun]Source :
- PLoS ONE [ 1932-6203 ] ; 2019.
Abstract
In 2009, Influenza A(H1N1)pdm09 caused the first influenza pandemic of the 21st century with high mortality rates of about 284 500 deaths. This virus, however, continues to circulate as a seasonal influenza virus and to cause illness and deaths worldwide. In this study, we describe the genetic diversity of A(H1N1)pdm09 viruses collected between 2014 and 2016 in Cameroon. Three gene segments (HA, NA and M) of Cameroon strains were studied. The phylogenetic tree of the coding nucleotide sequences was generated by MEGA version 6.0 using a Maximum Likelihood method. The NA and M protein coding sequences were analyzed for the reported genetic markers of resistance against neuraminidase inhibitors and adamantanes, while predicted vaccine efficacy was estimated using the Pepitope method. Overall 39 strains were obtained. Phylogenetic analysis of the HA gene of influenza A(H1N1)pdm09 showed that Cameroon strains belonged to two major clades. The 2014 Cameroon sequences belonged to clade 6C while all sequences collected between 2015 and 2016 belonged to clade 6B. Majority of the samples had some mutations in the NA gene notably: I117M, N248D, and N369K while the amantadine-resistant M mutant, S31N, was found to be absent only in the two sequences collected in 2014. Overall, A/California/07/2009 vaccine strain showed a predicted vaccine efficacy of 24.55% to 35.77% against Cameroon A(H1N1)pdm09 strains circulating between 2014 and 2016. Our findings confirms the fast evolution of A(H1N1)pdm09 since its first introduction and highlights on the importance of influenza vaccine in reducing the burden caused by influenza in the community.
Url:
DOI: 10.1371/journal.pone.0210119
PubMed: 30640922
PubMed Central: 6331099
Affiliations:
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Monamele</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>University of Buea, Buea, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>University of Buea, Buea</wicri:regionArea><wicri:noRegion>Buea</wicri:noRegion></affiliation></author><author><name sortKey="Munshili Njifon, Hermann Landry" sort="Munshili Njifon, Hermann Landry" uniqKey="Munshili Njifon H" first="Hermann Landry" last="Munshili Njifon">Hermann Landry Munshili Njifon</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre Pasteur of Cameroon, Annex of Garoua, Garoua, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Centre Pasteur of Cameroon, Annex of Garoua, Garoua</wicri:regionArea><wicri:noRegion>Garoua</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>University of Yaoundé 1, Yaoundé, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>University of Yaoundé 1, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation></author><author><name sortKey="Vernet, Marie Astrid" sort="Vernet, Marie Astrid" uniqKey="Vernet M" first="Marie-Astrid" last="Vernet">Marie-Astrid Vernet</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation></author><author><name sortKey="Njankouo, Mohamadou Ripa" sort="Njankouo, Mohamadou Ripa" uniqKey="Njankouo M" first="Mohamadou Ripa" last="Njankouo">Mohamadou Ripa Njankouo</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation></author><author><name sortKey="Kenmoe, Sebastien" sort="Kenmoe, Sebastien" uniqKey="Kenmoe S" first="Sebastien" last="Kenmoe">Sebastien Kenmoe</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation></author><author><name sortKey="Yahaya, Ali Ahmed" sort="Yahaya, Ali Ahmed" uniqKey="Yahaya A" first="Ali Ahmed" last="Yahaya">Ali Ahmed Yahaya</name><affiliation><nlm:aff id="aff005"><addr-line>World Health Organisation, Regional Office for Africa, Brazzaville, Congo</addr-line></nlm:aff><wicri:noCountry code="subfield">Congo</wicri:noCountry></affiliation></author><author><name sortKey="Deweerdt, Louis" sort="Deweerdt, Louis" uniqKey="Deweerdt L" first="Louis" last="Deweerdt">Louis Deweerdt</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre Pasteur of Cameroon, Annex of Garoua, Garoua, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Centre Pasteur of Cameroon, Annex of Garoua, Garoua</wicri:regionArea><wicri:noRegion>Garoua</wicri:noRegion></affiliation></author><author><name sortKey="Nono, Raphael" sort="Nono, Raphael" uniqKey="Nono R" first="Raphael" last="Nono">Raphael Nono</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre Pasteur of Cameroon, Annex of Garoua, Garoua, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>Centre Pasteur of Cameroon, Annex of Garoua, Garoua</wicri:regionArea><wicri:noRegion>Garoua</wicri:noRegion></affiliation></author><author><name sortKey="Mbacham, Wilfred" sort="Mbacham, Wilfred" uniqKey="Mbacham W" first="Wilfred" last="Mbacham">Wilfred Mbacham</name><affiliation wicri:level="1"><nlm:aff id="aff004"><addr-line>University of Yaoundé 1, Yaoundé, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>University of Yaoundé 1, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation></author><author><name sortKey="Anong, Damian Nota" sort="Anong, Damian Nota" uniqKey="Anong D" first="Damian Nota" last="Anong">Damian Nota Anong</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>University of Buea, Buea, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>University of Buea, Buea</wicri:regionArea><wicri:noRegion>Buea</wicri:noRegion></affiliation></author><author><name sortKey="Akoachere, Jane Francis" sort="Akoachere, Jane Francis" uniqKey="Akoachere J" first="Jane Francis" last="Akoachere">Jane Francis Akoachere</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>University of Buea, Buea, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>University of Buea, Buea</wicri:regionArea><wicri:noRegion>Buea</wicri:noRegion></affiliation></author><author><name sortKey="Njouom, Richard" sort="Njouom, Richard" uniqKey="Njouom R" first="Richard" last="Njouom">Richard Njouom</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé, Cameroon</addr-line></nlm:aff><country xml:lang="fr">Cameroun</country><wicri:regionArea>National Influenza Centre, Centre Pasteur of Cameroon, Yaoundé</wicri:regionArea><wicri:noRegion>Yaoundé</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In 2009, Influenza A(H1N1)pdm09 caused the first influenza pandemic of the 21st century with high mortality rates of about 284 500 deaths. This virus, however, continues to circulate as a seasonal influenza virus and to cause illness and deaths worldwide. In this study, we describe the genetic diversity of A(H1N1)pdm09 viruses collected between 2014 and 2016 in Cameroon. Three gene segments (HA, NA and M) of Cameroon strains were studied. The phylogenetic tree of the coding nucleotide sequences was generated by MEGA version 6.0 using a Maximum Likelihood method. The NA and M protein coding sequences were analyzed for the reported genetic markers of resistance against neuraminidase inhibitors and adamantanes, while predicted vaccine efficacy was estimated using the P<sub>epitope</sub> method. Overall 39 strains were obtained. Phylogenetic analysis of the HA gene of influenza A(H1N1)pdm09 showed that Cameroon strains belonged to two major clades. The 2014 Cameroon sequences belonged to clade 6C while all sequences collected between 2015 and 2016 belonged to clade 6B. Majority of the samples had some mutations in the NA gene notably: I117M, N248D, and N369K while the amantadine-resistant M mutant, S31N, was found to be absent only in the two sequences collected in 2014. Overall, A/California/07/2009 vaccine strain showed a predicted vaccine efficacy of 24.55% to 35.77% against Cameroon A(H1N1)pdm09 strains circulating between 2014 and 2016. Our findings confirms the fast evolution of A(H1N1)pdm09 since its first introduction and highlights on the importance of influenza vaccine in reducing the burden caused by influenza in the community.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrauwen, Eja" uniqKey="Schrauwen E">EJA Schrauwen</name></author><author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilbourne, Ed" uniqKey="Kilbourne E">ED Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name></author><author><name sortKey="Iuliano, Ad" uniqKey="Iuliano A">AD Iuliano</name></author><author><name sortKey="Reed, C" uniqKey="Reed C">C Reed</name></author><author><name sortKey="Meltzer, Mi" uniqKey="Meltzer M">MI Meltzer</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author><author><name sortKey="Cheng, P Y" uniqKey="Cheng P">P-Y Cheng</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lamb, Ra" uniqKey="Lamb R">RA Lamb</name></author><author><name sortKey="Krug, Rm" uniqKey="Krug R">RM Krug</name></author><author><name sortKey="Knipe, Dm" uniqKey="Knipe D">DM Knipe</name></author><author><name sortKey="Howley, P M" uniqKey="Howley P">P.M. Howley</name></author><author><name sortKey="Griffin, D E" uniqKey="Griffin D">D.E. Griffin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouvier, Nm" uniqKey="Bouvier N">NM Bouvier</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name></author><author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Igarashi, M" uniqKey="Igarashi M">M Igarashi</name></author><author><name sortKey="Ito, K" uniqKey="Ito K">K Ito</name></author><author><name sortKey="Yoshida, R" uniqKey="Yoshida R">R Yoshida</name></author><author><name sortKey="Tomabechi, D" uniqKey="Tomabechi D">D Tomabechi</name></author><author><name sortKey="Kida, H" uniqKey="Kida H">H Kida</name></author><author><name sortKey="Takada, A" uniqKey="Takada A">A Takada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eshaghi, A" uniqKey="Eshaghi A">A Eshaghi</name></author><author><name sortKey="Duvvuri, Vr" uniqKey="Duvvuri V">VR Duvvuri</name></author><author><name sortKey="Li, A" uniqKey="Li A">A Li</name></author><author><name sortKey="Patel, Sn" uniqKey="Patel S">SN Patel</name></author><author><name sortKey="Bastien, N" uniqKey="Bastien N">N Bastien</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barr, Ig" uniqKey="Barr I">IG Barr</name></author><author><name sortKey="Russell, C" uniqKey="Russell C">C Russell</name></author><author><name sortKey="Besselaar, Tg" uniqKey="Besselaar T">TG Besselaar</name></author><author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name></author><author><name sortKey="Daniels, Rs" uniqKey="Daniels R">RS Daniels</name></author><author><name sortKey="Donis, R" uniqKey="Donis R">R Donis</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Gupta, V" uniqKey="Gupta V">V Gupta</name></author><author><name sortKey="Earl, Dj" uniqKey="Earl D">DJ Earl</name></author><author><name sortKey="Deem, Mw" uniqKey="Deem M">MW Deem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Mi" uniqKey="Nelson M">MI Nelson</name></author><author><name sortKey="Njouom, R" uniqKey="Njouom R">R Njouom</name></author><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name></author><author><name sortKey="Niang, Mn" uniqKey="Niang M">MN Niang</name></author><author><name sortKey="Kadjo, H" uniqKey="Kadjo H">H Kadjo</name></author><author><name sortKey="Ampofo, W" uniqKey="Ampofo W">W Ampofo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monamele, Gc" uniqKey="Monamele G">GC Monamele</name></author><author><name sortKey="Vernet, Ma" uniqKey="Vernet M">MA Vernet</name></author><author><name sortKey="Njankouo, Mr" uniqKey="Njankouo M">MR Njankouo</name></author><author><name sortKey="Victoir, K" uniqKey="Victoir K">K Victoir</name></author><author><name sortKey="Akoachere, Jf" uniqKey="Akoachere J">JF Akoachere</name></author><author><name sortKey="Anong, D" uniqKey="Anong D">D Anong</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Deem, Mw" uniqKey="Deem M">MW Deem</name></author><author><name sortKey="Pan, K" uniqKey="Pan K">K Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hurt, Ac" uniqKey="Hurt A">AC Hurt</name></author><author><name sortKey="Besselaar, Tg" uniqKey="Besselaar T">TG 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uniqKey="Wandaogo S">SCM Wandaogo</name></author><author><name sortKey="Poda, A" uniqKey="Poda A">A Poda</name></author><author><name sortKey="Tamini, L" uniqKey="Tamini L">L Tamini</name></author><author><name sortKey="Kyere, Ae" uniqKey="Kyere A">AE Kyere</name></author><author><name sortKey="Sagna, T" uniqKey="Sagna T">T Sagna</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korsun, N" uniqKey="Korsun N">N Korsun</name></author><author><name sortKey="Angelova, S" uniqKey="Angelova S">S Angelova</name></author><author><name sortKey="Gregory, V" uniqKey="Gregory V">V Gregory</name></author><author><name sortKey="Daniels, R" uniqKey="Daniels R">R Daniels</name></author><author><name sortKey="Georgieva, I" uniqKey="Georgieva I">I Georgieva</name></author><author><name sortKey="Mccauley, J" uniqKey="Mccauley J">J McCauley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tewawong, N" uniqKey="Tewawong N">N Tewawong</name></author><author><name sortKey="Prachayangprecha, S" uniqKey="Prachayangprecha S">S Prachayangprecha</name></author><author><name sortKey="Vichiwattana, P" uniqKey="Vichiwattana P">P Vichiwattana</name></author><author><name sortKey="Korkong, S" uniqKey="Korkong S">S Korkong</name></author><author><name sortKey="Klinfueng, S" uniqKey="Klinfueng S">S Klinfueng</name></author><author><name sortKey="Vongpunsawad, S" uniqKey="Vongpunsawad S">S Vongpunsawad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wedde, M" uniqKey="Wedde M">M Wedde</name></author><author><name sortKey="Biere, B" uniqKey="Biere B">B Biere</name></author><author><name sortKey="Wolff, T" uniqKey="Wolff T">T Wolff</name></author><author><name sortKey="Schweiger, B" uniqKey="Schweiger B">B Schweiger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name></author><author><name sortKey="Sun, N" uniqKey="Sun N">N Sun</name></author><author><name sortKey="Lv, Q Y" uniqKey="Lv Q">Q-y Lv</name></author><author><name sortKey="Liu, D H" uniqKey="Liu D">D-h Liu</name></author><author><name sortKey="Liu, D P" uniqKey="Liu D">D-p Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Njouom, R" uniqKey="Njouom R">R Njouom</name></author><author><name sortKey="Mba, Sa" uniqKey="Mba S">SA Mba</name></author><author><name sortKey="Noah, Dn" uniqKey="Noah D">DN Noah</name></author><author><name sortKey="Gregory, V" uniqKey="Gregory V">V Gregory</name></author><author><name sortKey="Collins, P" uniqKey="Collins P">P Collins</name></author><author><name sortKey="Cappy, P" uniqKey="Cappy P">P Cappy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Potdar, Va" uniqKey="Potdar V">VA Potdar</name></author><author><name sortKey="Dakhave, Mr" uniqKey="Dakhave M">MR Dakhave</name></author><author><name sortKey="Kulkarni, Pb" uniqKey="Kulkarni P">PB Kulkarni</name></author><author><name sortKey="Tikhe, Sa" uniqKey="Tikhe S">SA Tikhe</name></author><author><name sortKey="Broor, S" uniqKey="Broor S">S Broor</name></author><author><name sortKey="Gunashekaran, P" uniqKey="Gunashekaran P">P Gunashekaran</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pan, K" uniqKey="Pan K">K Pan</name></author><author><name sortKey="Subieta, Kc" uniqKey="Subieta K">KC Subieta</name></author><author><name sortKey="Deem, Mw" uniqKey="Deem M">MW Deem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mostafa, A" uniqKey="Mostafa A">A Mostafa</name></author><author><name sortKey="Abdelwhab, El Sm" uniqKey="Abdelwhab E">el SM Abdelwhab</name></author><author><name sortKey="Slanina, H" uniqKey="Slanina H">H Slanina</name></author><author><name sortKey="Hussein, Ma" uniqKey="Hussein M">MA Hussein</name></author><author><name sortKey="Kuznetsova, I" uniqKey="Kuznetsova I">I Kuznetsova</name></author><author><name sortKey="Schuttler, Cg" uniqKey="Schuttler C">CG Schuttler</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Cameroun</li></country></list><tree><noCountry><name sortKey="Yahaya, Ali Ahmed" sort="Yahaya, Ali Ahmed" uniqKey="Yahaya A" first="Ali Ahmed" last="Yahaya">Ali Ahmed Yahaya</name></noCountry><country name="Cameroun"><noRegion><name sortKey="Monamele, Chavely Gwladys" sort="Monamele, Chavely Gwladys" uniqKey="Monamele C" first="Chavely Gwladys" last="Monamele">Chavely Gwladys Monamele</name></noRegion><name sortKey="Akoachere, Jane Francis" sort="Akoachere, Jane Francis" uniqKey="Akoachere J" first="Jane Francis" last="Akoachere">Jane Francis Akoachere</name><name sortKey="Anong, Damian Nota" sort="Anong, Damian Nota" uniqKey="Anong D" first="Damian Nota" last="Anong">Damian Nota Anong</name><name sortKey="Deweerdt, Louis" sort="Deweerdt, Louis" uniqKey="Deweerdt L" first="Louis" last="Deweerdt">Louis Deweerdt</name><name sortKey="Kenmoe, Sebastien" sort="Kenmoe, Sebastien" uniqKey="Kenmoe S" first="Sebastien" last="Kenmoe">Sebastien Kenmoe</name><name sortKey="Mbacham, Wilfred" sort="Mbacham, Wilfred" uniqKey="Mbacham W" first="Wilfred" last="Mbacham">Wilfred Mbacham</name><name sortKey="Monamele, Chavely Gwladys" sort="Monamele, Chavely Gwladys" uniqKey="Monamele C" first="Chavely Gwladys" last="Monamele">Chavely Gwladys Monamele</name><name sortKey="Munshili Njifon, Hermann Landry" sort="Munshili Njifon, Hermann Landry" uniqKey="Munshili Njifon H" first="Hermann Landry" last="Munshili Njifon">Hermann Landry Munshili Njifon</name><name sortKey="Munshili Njifon, Hermann Landry" sort="Munshili Njifon, Hermann Landry" uniqKey="Munshili Njifon H" first="Hermann Landry" last="Munshili Njifon">Hermann Landry Munshili Njifon</name><name sortKey="Njankouo, Mohamadou Ripa" sort="Njankouo, Mohamadou Ripa" uniqKey="Njankouo M" first="Mohamadou Ripa" last="Njankouo">Mohamadou Ripa Njankouo</name><name sortKey="Njouom, Richard" sort="Njouom, Richard" uniqKey="Njouom R" first="Richard" last="Njouom">Richard Njouom</name><name sortKey="Nono, Raphael" sort="Nono, Raphael" uniqKey="Nono R" first="Raphael" last="Nono">Raphael Nono</name><name sortKey="Vernet, Marie Astrid" sort="Vernet, Marie Astrid" uniqKey="Vernet M" first="Marie-Astrid" last="Vernet">Marie-Astrid Vernet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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